在HIV-1暴露的血清阴性个体中的HIV-1保护性表位特异性CD8+ T细胞
Takayuki Chikata1, Hiroyuki Gatanaga2, Hung The Nguyen1
1Tokyo Laboratory and Division of International Collaboration Research, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto 162-0052, Japan.
iScience
|October 23, 2023
概括
在暴露于HIV的血清阴性男性中发现了识别保护性表位的HIV特异性CD8+T细胞. 这些发现表明,这些T细胞可能有助于预防HIV-1感染.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 之前的研究指出,HIV-1特异性T细胞对暴露于HIV的血清阴性 (HESN) 个体的反应.
- 缺乏对这些T细胞在预防HIV-1感染中的作用的详细分析.
研究的目的:
- 研究与男性发生性关系 (MSM) 的日本HESN男性的HIV-1特异性CD8+T细胞反应.
- 为了识别HESN个体中T细胞识别的特定HIV-1表位.
- 探索这些T细胞对抗HIV-1感染的潜在保护作用.
主要方法:
- 使用细胞内细胞因子染色试验对143种HIV-1表皮质的T细胞反应的分析.
- 在3周的培养中用激活周围血液单核细胞 (PBMCs).
- 鉴定HLA-B*51:01受限制的Pol TI8和HLA-A*02:06受限制的Pol SV9特定的CD8+T细胞.
主要成果:
- 在三个HESN-MSM个体中,发现了针对HLA-B*51:01受限制的Pol TI8和HLA-A*02:06受限制的Pol SV9表位的HIV-1特异性CD8+T细胞.
- 这些已识别的T细胞表现出对HIV-1感染细胞的识别.
- 在研究队列中没有检测到针对其他HLA-A*02:06或HLA-B*51:01表位体的特异性T细胞.
结论:
- 这项研究在HESN-MSM个体中确定了具有保护性表位特异性的CD8+T细胞.
- 这些T细胞可能在抑制HIV-1复制和预防感染方面发挥作用.
- 研究结果表明,特异性T细胞反应对抗HIV-1感染的自然保护有所贡献.
更多相关视频
相关概念视频
01:29Immune Response Against Viral Pathogens
798
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
798
01:22T Cell Activation and Clonal Selection
764
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
764
01:27Cytotoxic T Cells-mediated Immune Response
933
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
933