在呼吸道微生物组中应用多组组学:进展,挑战和承诺
Jingyuan Gao1, Xinzhu Yi1, Zhang Wang1
1Institute of Ecological Sciences, School of Life Sciences, South China Normal University, Guangzhou, Guangdong Province, China.
Computational and structural biotechnology journal
|October 23, 2023
概括
呼吸道微生物群现在使用多组学研究,整合各种数据类型,以全面了解肺部健康和疾病. 这种方法促进了从关联到因果关系的理解,尽管存在挑战.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
背景情况:
- 呼吸道微生物组领域已经进入了多原子时代.
- 整合多样化的欧米数据 (元基因组,元转录组等). 提供了对肺微生物组的整体见解.
研究的目的:
- 审查在研究呼吸道微生物群的应用多omics.
- 讨论呼吸道微生物组研究的挑战和未来方向.
主要方法:
- 介绍呼吸道样本类型和omic数据.
- 描述多原子集成方法 (缩小维度,关联,预测).
主要成果:
- 多组学使得呼吸道疾病中的肺微生物组从关联性转变为因果性理解.
- 总结了应用多组学在呼吸道疾病方面的进展.
结论:
- 多omics提供了对肺微生物组在呼吸系统疾病中的作用的有力见解.
- 在样本处理,数据集成和验证方面的挑战需要解决,以便在未来取得进展.
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