研究跨性别者的FGF21水平及其与代谢参数的关联
Lohit Kumbar1, Baratam Hari Kiran1, Mala Dharmalingam1
1Department of Endocrinology, M. S. Ramaiah Medical College, Bengaluru, Karnataka, India.
Indian journal of endocrinology and metabolism
|October 23, 2023
概括
纤维细胞生长因子21 (FGF21) 水平与输血女性的胆固醇和甘油三与正相关. 这表明FGF21可能表明这个人群中的代谢综合征风险.
科学领域:
- 内分泌学 在内分泌学.
- 代谢研究研究 代谢研究
- 跨性别者健康 跨性别者健康
背景情况:
- 纤维细胞生长因子21 (FGF21) 是一种关键的代谢调节剂,在2型糖尿病和脂质失调症中具有潜在的治疗应用.
- 在患有性别失调症的个体中,FGF21的特定作用和水平在很大程度上仍未得到研究.
- 这项研究探讨了FGF21在跨性别个体的代谢概况中的参与.
研究的目的:
- 确定跨性别个体 (变性女性和变性男性) 的纤维细胞生长因子21 (FGF21) 水平,并将其与异性对照进行比较.
- 调查FGF21水平与关键代谢参数 (包括脂质和葡萄糖) 之间的关联,在跨性别群体中.
- 探索FGF21水平的潜在差异及其基于跨性别人口中性别认同的相关性.
主要方法:
- 横截面研究比较了23名变性女性和21名变性女性与44名 cisgender 对照.
- 测量血清纤维细胞生长因子21 (FGF21) 的水平.
- 分析脂质特征 (总胆固醇,LDL胆固醇,甘油三) 和禁食血糖.
- 统计分析包括单变量和多变量相关性.
主要成果:
- 虽然FGF21水平在变性女性中比变性女性和对照人群数目上更高,但这些差异在统计学上并不显著.
- 单变量分析显示,FGF21水平与血清总胆固醇和LDL胆固醇在输血女性中存在正相关性,但在跨男性中没有.
- 多变量分析,使用对照FGF21水平的第75百分位数作为切断值,证实了FGF21,总胆固醇和LDL胆固醇之间的显著正相关性,特别是在输血女性中.
结论:
- 纤维细胞生长因子21 (FGF21) 水平与输血女性的血清甘油三和LDL胆固醇有显著的正相关性.
- 这些发现表明,FGF21可以作为一个有价值的生物标志物,用于预测转化女性代谢综合征的发展.
- 需要进一步的研究来阐明FGF21在跨性别代谢健康中的精确机制和临床影响.
关键词:
FGF21FGF21FGF21FGF21FGF21FGF21FGF21FGF21FGF21FGF21F葡萄糖 葡萄糖 葡萄糖 葡萄糖脂质脂质是什么意思 脂质脂质是什么意思代谢综合征代谢综合征变性人是指变性人,是指变性人.更多相关视频
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