针对干扰素1型的自身抗体在COVID-19严重性中的作用:系统性审查和元分析
Abolfazl Akbari1, Alireza Hadizadeh2,3, Mahdi Amiri1
1Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
第一种类型的干扰素自身抗体 (aIFN-1) 与严重的COVID-19有关. 这一系统性审查发现aIFN-1及其亚型在危急病例中更为普遍,并预测了糟糕的结果,特别是在男性中.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 传染性疾病 传染性疾病
背景情况:
- I型干扰素 (IFN-I) 信号受损与严重的COVID-19相关.
- 针对IFN-I的自身抗体 (AAbs) 可能会影响抗病毒反应.
研究的目的:
- 系统地审查和元分析COVID-19严重程度和IFN-I自身抗体 (aIFN-1) 之间的关联.
- 在COVID-19患者中调查aIFN-1及其亚型 (aIFN-α,aIFN-ω,aIFN-β) 的流行率和预后价值.
主要方法:
- 在四个主要数据库 (Medline,Embase,Web of Science,Scopus) 进行系统搜索.
- 对33项研究的数据进行了元分析,其中包括13023名患者.
- 对疾病结果 (ICU入院,死亡) 和中和和循环自身抗体的流行率的几率比率的计算.
主要成果:
- 循环aIFN-1的总流行率为17.8%,中和aIFN-1的总流行率为7.1%.
- 循环和中和aIFN-α和中和aIFN-ω在严重/危急的COVID-19患者中明显更频繁.
- 反IFN-1自身抗体在男性中更常见,并且与急症监护室入院和死亡的增加有关.
结论:
- I型干扰素自身抗体与严重和危急的COVID-19有关.
- 这些自身抗体可能作为COVID-19预后不佳的预测标志物,特别是在男性中.
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