抑郁和疲劳是由于多发性硬化症中阻断性睡眠喘引起的
Mario Mihalj1,2, Zrinka Janković2, Eni Jadrijević Kodžoman1
1Department of Neurology, Split University Hospital Center, Split, Croatia.
Acta clinica Croatica
|October 23, 2023
概括
多发性硬化症 (MS) 患者的疲劳和抑郁症与阻塞性睡眠呼吸暂停 (OSA) 有关,而不是MS本身. 这表明OSA是这些常见的MS症状的次要原因.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 精神病学是一个精神病学.
背景情况:
- 疲劳和抑郁是患有多发性硬化症 (MS) 的患者普遍出现的症状.
- 阻塞性睡眠呼吸暂停 (OSA) 也在MS患者中很常见,但其对疲劳和抑郁的贡献尚不清楚.
- 现有的研究还没有区分这些症状是否源于MS的主要机制,还是像OSA这样的二次条件.
研究的目的:
- 调查MS患者疲劳和抑郁症之间的关联以及OSA的临床特征.
- 为了确定这些症状是否与MS疾病特征或二次疾病有关.
主要方法:
- 一项调查研究对28名确诊多发性硬化症的门诊患者进行了调查.
- 使用了经过验证的问卷:STOP-BANG (OSA风险),爱普沃思睡眠度量表 (白天睡眠),疲劳严重度量表和流行病学研究中心抑郁症度量表修订.
- 数据分析探讨了MS特征,OSA风险,嗜睡,抑郁和疲劳之间的相关性.
主要成果:
- 29%的多发性硬化患者有增加的OSA风险,与年龄相关.
- 多发性硬化症的临床特征 (亚型,残疾,持续时间,治疗) 与抑郁或疲劳没有相关性.
- 过度的白天嗜睡 (OSA的标志) 与更高水平的抑郁和疲劳有显著的关联.
- 抑郁症与增加的OSA风险和患者年龄相关.
- 疲劳的严重程度与抑郁症状水平相关.
结论:
- 阻塞性睡眠呼吸暂停在多发性硬化症患者中很常见.
- 在MS患者中,抑郁和疲劳的症状与OSA风险因素和过度的白天嗜睡有关.
- 研究结果支持这样的假设,即OSA是MS中疲劳和抑郁症的重要次要因素.
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