在住院COVID-19患者中探索anellovirus负载和临床变量之间的关系:对免疫激活和炎症的影响
Marijn Thijssen1, Timothy Devos2, Geert Meyfroidt3
1KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory for Clinical and Epidemiological Virology, Leuven, Belgium.
IJID regions
|October 23, 2023
概括
住院COVID-19患者在入院时的anellovirus负载较高. 这种病毒载量与炎症标志物相关,与抗体反应相反,这表明它反映了免疫激活.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 类病毒是已知与宿主免疫能力和炎症相关的DNA病毒.
- 了解特定患者群体的病毒载荷,如COVID-19住院患者,对于评估疾病影响和宿主反应至关重要.
研究的目的:
- 为了调查住院COVID-19患者的anellovirus负载.
- 探索anellovirus负载和临床变量之间的关联,包括治疗和炎症和器官损伤的标志物.
主要方法:
- 在第0天和第6天从150名住院COVID-19患者 (DAWN-Plasma试验) 收集了血样本.
- 量化了anellovirus负载,并使用多变量模型将临床变量与病毒负载变化联系起来.
主要成果:
- 与第6天相比,Anellovirus负载在第0天较高,仅接受标准护理 (SOC) 的患者观察到显著下降.
- 接受免疫抑制药物的患者表现出较低的anellovirus负载,而急诊室的入院与更高的负载有关.
- 炎症和器官损伤标志物 (D-二聚体,乳酸脱酶) 与anellovirus负载正相关.
- 在0日的anellovirus负载与SARS-CoV-2抗体反应有负相关性.
结论:
- 在COVID-19患者中的anellovirus负载与与免疫能力和炎症相关的各种临床因素有关.
- 这项研究表明,anellovirus的丰富程度可以作为这些患者免疫激活净状态的指标.
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