哈维大鼠肉瘤病毒突变对口腔状细胞癌的影响及其对不同人群的影响:系统性审查
Mudiyayirakkani Muthusamy1, Pratibha Ramani2, Paramasivam Arumugam3
1Department of Oral and Maxillofacial Pathology, Saveetha Dental College and Hospitals, Chennai, IND.
Cureus
|October 23, 2023
概括
哈维大鼠肉瘤病毒 (HRAS) 瘤基因的突变破坏了细胞调节,导致癌症发病. 这篇评论探讨了HRAS.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学是一种遗传学.
背景情况:
- 基因为蛋白质合成提供信息,控制细胞生长,分化,成熟和死亡.
- 像哈维大鼠肉瘤病毒 (HRAS) 这样的基因突变可以破坏这些功能,导致癌细胞转变.
- HRAS是一种对调节细胞分裂至关重要的瘤基因;它的突变与各种癌症有关,特别是头癌.
研究的目的:
- 调查HRAS突变在口腔状细胞癌 (OSCC) 发病过程中的尚未探索的机制.
- 系统地审查和总结HRAS突变在OSCC病变发生中的作用.
- 检查HRAS的分子网络及其对致癌的贡献.
主要方法:
- 在PubMed,Scopus和Web of Science数据库中进行了系统的文献搜索.
- 分析的重点是Ras-依赖突变及其对Ras-Raf-MAPK信号通路的影响.
- 该审查检查了涉及HRAS介导致癌的分子网络和信号通路.
主要成果:
- HRAS突变放松Ras-Raf-MAPK通路的调节,影响上游和下游组件,导致瘤发生.
- 拉斯突变可以在各个阶段影响拉斯-拉夫-MAPK通路,影响细胞分裂,分化,生长,存活和细胞周期.
- HRAS突变的频率和类型影响疾病的结果和细胞反应.
结论:
- HRAS突变在驱动致癌的分子网络中起着至关重要的作用,特别是在OSCC中.
- 了解HRAS突变机制对于阐明OSCC病原性至关重要.
- 受到信号分子影响的分子网络的复杂平衡对于确定癌症发展中的细胞结果至关重要.
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