产后情绪障碍的甲状腺预测因子
Sean Backer1, Janeta Yancheva2, Camelia Garcia3
1Osteopathic Medicine, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Tampa, USA.
Cureus
|October 23, 2023
概括
甲状腺自身免疫,特别是抗甲状腺过氧化酶 (TPO) 抗体,可以预测晚期产后抑郁症 (PPD). 产后皮质醇下降可以触发TPO阳性女性的甲状腺自身免疫,导致甲状腺功能低下和抑郁症状.
科学领域:
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
- 生殖医学 生殖医学
背景情况:
- 产后情绪障碍 (PMD) 是孕产妇发病率和死亡率的重要原因.
- 产后忧郁症的确切原因,包括产后忧郁症 (PB) 和产后抑郁症 (PPD),尚不清楚,荷尔蒙波动是主要假设.
- 甲状腺功能与精神疾病有关,但其在PMD中的特定作用需要进一步调查.
研究的目的:
- 调查甲状腺功能与PMD之间的病理生理联系.
- 评估甲状腺标记物在预测PMD的发生和严重程度方面的潜力.
- 为了探索甲状腺自身免疫和产后抑郁症状之间的关系.
主要方法:
- 进行了叙事文学评论.
- 在PubMed上使用特定的包含和排除标准进行了搜索.
- 包括检查甲状腺标志物与PMD发生率或病理生理学相关的研究.
主要成果:
- 甲状腺自身免疫性显示出作为晚发性PPD的预测因素的潜力.
- 甲状腺功能低下,低甲状腺激素水平和甲状腺自身抗体与增加的PPD发病率相关.
- 产后皮质醇下降可能会诱导抗TPO抗体阳性女性的甲状腺自身免疫,可能导致甲状腺功能低下和抑郁症状.
结论:
- 甲状腺自身免疫,特别是第三个三个月的TPO抗体,可以作为晚期PPD的预测因素.
- 虽然PMD的发病因子仍然含糊不清,但甲状腺功能标志物提供了潜在的见解.
- 没有足够的证据将甲状腺功能与分娩后精神病联系起来.
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