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与他类药物相关的自身免疫性肌肉缺陷伪装成老年人经常性跌倒
Malarkodi Suppamutharwyam1, Tunku Muzafar Shah1
1Geriatrics, Selayang General Hospital, Batu Caves, MYS.
Cureus
|October 23, 2023
概括
类他类药物相关的自身免疫肌病是一种罕见但严重的疾病,导致持续的肌肉衰弱. 早期识别和免疫抑制治疗对于控制这种破坏性副作用至关重要.
科学领域:
- 神经学 神经学
- 类风湿病学 类风湿病学
- 临床药理学 临床药理学
背景情况:
- 类药物通常用于预防心血管疾病.
- 达丁类药物诱导的肌肉病是常见的不良反应,通常在药物戒药时会消失.
- 类他类药物相关的自身免疫肌肉病变 (SAAM) 是一种非常罕见的,严重的并发症,特征是持续的肌肉衰弱和肌酸激酶水平升高,即使在停止使用类他类药物后也是如此.
研究的目的:
- 为了呈现一个具有挑战性的病例,他类药物相关的自身免疫肌肉病变.
- 突出这一罕见疾病的诊断和治疗考虑因素.
主要方法:
- 病例报告详细介绍了一个患有衰弱肌肉的患者.
- 对临床表现,实验室发现 (包括肌酸激酶水平) 和治疗反应的审查.
- 讨论SAAM的诊断标准和管理策略.
主要成果:
- 患者在使用阿托瓦斯塔丁十年后出现了严重的,持续的肌肉衰弱和较高的肌酸激酶水平.
- 肌肉软弱和实验室异常仍然存在,尽管停用了他类药物.
- 患者在免疫抑制疗法后表现出改善.
结论:
- 类他类药物相关的自身免疫性肌肉病变是一种关键的诊断,应考虑在患有持续肌肉衰弱的患者中,尽管他类药物已停用.
- 及时识别和启动免疫抑制疗法对于减少与SAAM相关的发病率和死亡率至关重要.
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