在体外受精中,双重触发的结果在对手周期中的normoresponders中具有双重触发
Munire Funda Cevher Akdulum1, Seçil İrem Arık1, Erhan Demirdağ2
1Obstetrics and Gynaecology, Gazi University, Ankara, TUR.
Cureus
|October 23, 2023
概括
使用GnRH激动剂和hCG激发排卵的双重触发方法比单独的hCG更有效,可以提高正常响应者在IVF周期中的成熟卵细胞产量和持续怀孕率. 这种方法提高了胚胎质量和成熟率,在接受卵巢刺激的患者中使用GnRH抗剂协议进行卵巢刺激.
科学领域:
- 生殖内分泌学和不孕不育问题
- 辅助生殖技术 (ART) 是一种辅助生殖技术.
- 妇科 妇科医生 妇科
背景情况:
- 优化排卵诱导协议对于改善体外受精 (IVF) 成功率至关重要.
- 选择排卵触发药物可以显著影响卵细胞成熟和随后的怀孕结果.
- 对卵巢刺激反应良好的患者 (正常反应者) 可能会从特定的触发策略中受益.
研究的目的:
- 在试管婴儿周期中,比较双触发剂 (GnRH激动剂加hCG) 与标准hCG触发剂的疗效.
- 评估双触发对正常反应患者卵细胞产量,胚胎质量和怀孕率的影响.
- 评估GnRH对抗剂协议中的双触发器对卵巢刺激的有效性.
主要方法:
- 在2013年1月至2021年12月期间,对5593个对抗剂周期的回顾性审查.
- 纳入标准:腹卵泡数 ≥5,对卵巢刺激的正常反应 (FORT) 和GnRH对抗剂协议.
- 标准hCG触发组 (383个周期) 和双触发组 (861个周期) 之间的结果比较.
主要成果:
- 双触发组显示出显著更高数量的成熟卵细胞和高质量的胚胎.
- 卵细胞成熟率在双触发组 (76.9%) 与hCG组 (74.8%) 相比,在双触发组中更高,p=0.018.
- 持续怀孕率在双重触发器 (37.6%) 与单独hCG (30.1%) 相比显著改善,p=0.02.
结论:
- 双触发策略优于单独的hCG,可以提高正常反应型IVF患者的成熟卵细胞产量和胚胎质量.
- 在这种患者群体中,双重触发显著增加了与hCG单疗相比的持续怀孕率.
- 这些发现支持在试管婴儿周期中使用双排卵触发的方法,使用GnRH对抗剂协议用于正常反应者.
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