抗吸收疗法在患有骨转移的患者中使用率低且不成比例
Amil R Agarwal1,2, Christa L LiBrizzi2, Lauren Wessel3
1Department of Orthopaedic Surgery, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Journal of bone oncology
|October 23, 2023
概括
抗吸收疗法在骨转移患者中未得到充分利用,只有7.7%的患者接受了它. 这种疗法可降低病理骨折风险,突出需要解决处方差异以获得更好的患者结果.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 抗吸收疗法对于治疗骨转移性疾病患者的骨相关事件至关重要.
- 关于这些疗法在预防病理性骨折方面的处方率和有效性的数据有限.
研究的目的:
- 确定在诊断后两年内接受抗吸收疗法的骨转移患者的比例.
- 在这个人群中识别与病理骨折相关的因素.
- 为了确定与接受抗吸收疗法相关的因素.
主要方法:
- 马里纳号数据集 (2010年1月至2021年10月) 的分析,包括696,459名新诊断骨转移的患者.
- 使用国际疾病分类 (ICD) 10 个代码来识别患者.
- 采用考克斯比例危险比率模型来评估病理骨折和抗吸收治疗处方的风险因素.
主要成果:
- 只有7.7%的患者接受了抗吸收疗法;7.3%的患者在两年内出现了病理性骨折.
- 在年轻患者 (35-44岁) 中观察到病理骨折的风险更高,患有癌,多发性骨髓瘤和医疗补助保险的人.
- 抗吸收疗法显著降低了病理骨折的风险 (HR 0.71).
- 年龄的增加预测了抗吸收疗法的处方,而男性性别和前列腺癌,肺癌或癌的诊断是负面预测因素.
结论:
- 抗吸收疗法的利用率 (7.7%) 尽管在减少病理性骨折方面已被证明有效,但仍然很低.
- 处方模式的差异被注意到,年轻的患者,男性和患有特定癌症的人不太可能接受治疗.
- 增加提供者的努力对于改善抗吸收疗法的采用和减少处方差异至关重要.
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