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平均血小板体积在预测和诊断子宫前方面的临床价值:系统性审查和元分析

Dan Ye¹, Shuwen Li², Yi Ding¹

¹The Second Clinical Medical College, Lanzhou University, Lanzhou, China.

Frontiers in cardiovascular medicine

|October 23, 2023

概括

平均血小板体积 (MPV) 显示出适度的预测价值,用于预先 (PE) 诊断,特别是在怀孕20周后. 将MPV与其他标记物结合起来可以改善PE分化.

科学领域:

产科和妇科产科和妇科
血液学血液学血液学
诊断准确性研究诊断准确性研究

背景情况:

孕前 (PE) 是一种严重的妊娠并发症,与血小板缩和血小板功能障碍有关.
平均血小板体积 (MPV) 是一个血小板功能标志物,研究其在PE诊断中的预测潜力.

研究的目的:

系统地评估MPV的诊断准确性,以诊断妊娠前 (PE).
评估MPV在不同妊娠期的预测价值,并确定最佳切断值.

主要方法:

在多个数据库 (PubMed,Embase,Cochrane Library等) 进行了全面的文献搜索. 在2023年3月13日之前.
包括评估MPV用于PE诊断的诊断准确性研究.
使用元分析技术将灵敏度,特异性和其他诊断性能指标汇集在一起.

主要成果:

在PE识别中MPV的综合诊断准确度显示灵敏度为0.676和特异性为0.710.
在怀孕20周后诊断出PE的诊断准确度更高.
当MPV切断值在9和10fL之间时,观察到最佳诊断性能,SROC-AUC为0.8856.6,MPV切断值在9和10fL之间,SROC-AUC为0.8856.

结论:

MPV对PE具有适度的预测和诊断价值,特别是在晚期怀孕中.
单单MPV的敏感性是有限的;将其与其他标记物结合起来可以增强PE的分化.
在PE诊断中,MPV切线值在9到10fL之间似乎最有效.

关键词:

诊断诊断诊断诊断诊断诊断血小板的平均体积是多少这是一个元分析.孕产妇产前症 (pre-eclampsia) 是一个疾病.预防预防预防

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