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帕金森病中的冲动性特征:系统审查和元分析

Fabio Giovannelli¹, Gioele Gavazzi¹, Chiara Noferini^1,2

¹Department of Neuroscience, Psychology, Drug Research and Child's Health (NEUROFARBA), Section of Psychology University of Florence Florence Italy.

Movement disorders clinical practice

|October 23, 2023

概括

与健康个体相比,帕金森病患者的特征冲动性更高. 这种冲动性在治疗期间发展出冲动控制障碍 (ICD) 的PD患者中更加明显.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
运动障碍运动障碍

背景情况:

冲动性作为一种人格特质是帕金森病 (PD) 患者进行多巴胺疗法的冲动控制障碍 (ICD) 的潜在危险因素.
关于PD患者与对照患者的特征冲动性差异,以及具有与没有ICD的PD患者的特征冲动性差异的先前研究已经产生了不一致的结果.

研究的目的:

在帕金森病 (PD) 患者中,系统地审查和元分析比较特征冲动性的研究,用巴拉特冲动性量表 (BIS-11) 测量.
为了比较PD患者和健康对照者之间的BIS-11分数.
为了比较PD患者与没有冲动控制障碍 (ICD) 之间的BIS-11分数.

主要方法:

在三个数据库中进行了系统的搜索,以确定符合条件的研究.
进行了元分析,以计算BIS-11总和分量级分数的平均差异和95%置信区间.
使用元回归来调查异质性的潜在来源,包括患者人口统计和药物剂量.

主要成果:

分析包括了40项研究.
与健康对照组相比,帕金森病 (PD) 患者的BIS-11总分数显著更高 (平均差异2.43;95% CI,1.03,3.83).
患有活跃冲动控制障碍 (ICD) 的PD患者的BIS-11总得分明显高于没有ICD的患者 (平均差异6.62;95%CI,5.01,8.23).

结论:

提升的特征冲动性是帕金森病 (PD) 患者的特征,无论冲动控制障碍 (ICD) 状态如何.
这些发现加强了现有的临床观察,在患有ICD的PD患者中增加了特征冲动性.

关键词:

巴拉特冲动度量表巴拉特冲动度量表帕金森病是帕金森病的一种.冲动控制障碍冲动控制障碍冲动性是一种冲动性.

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