流体细胞调节瘤球状体的机制
Ayushi Agrawal1, Soufian Lasli1, Yousef Javanmardi1
1Department of Mechanical Engineering, University College London, London, WC1E 7JE, UK.
Materials today. Bio
|October 23, 2023
概括
癌细胞通过重塑细胞外基质 (ECM) 来入侵. 将 stromal 细胞纳入试验,提高了癌细胞的侵入性,改变了 ECM 变形,突出了瘤微环境的作用.
科学领域:
- 生物物理学的生物物理.
- 癌症生物学 癌症生物学
- 细胞微环境研究研究
背景情况:
- 癌细胞具有收缩性,使其能够进行细胞外基质 (ECM) 改造以扩散.
- 研究瘤生长和ECM重塑,但细胞瘤微环境 (TME) 对癌细胞介导的ECM变形的影响往往被忽视.
研究的目的:
- 为了研究TME内部的 stromal 细胞如何影响癌症球体收缩性,ECM重塑和入侵.
- 开发和使用一种新的体外检测方法来量化TME驱动的癌症球体ECM变形.
主要方法:
- 开发一种多层in vitro测定方法,将癌细胞与癌症球体结合在一起.
- 量化球体对ECM施加的收缩变形的量化.
- 对原变形水平和癌细胞侵入性的分析.
主要成果:
- 在球体入侵潜力和原变形水平之间观察到负相关性.
- 流体细胞显著增强了癌细胞的侵入性,并改变了原体凝的变形和重新调整.
- 肌体细胞对促炎性细胞因子的升级被确定为驱动癌细胞侵入性增加的机制.
结论:
- 细胞TME,特别是层状细胞,在调节癌细胞入侵和ECM重塑方面发挥着关键作用.
- 矩阵变形测量可以作为评估癌症侵入性的生物物理标记.
- 研究结果表明,针对TME相互作用的潜在治疗策略可以调节癌细胞入侵.
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