探索B细胞在固体瘤中的双重作用:对头部和部状细胞癌的含义
Jiantong Bao1,2, Annika C Betzler1, Jochen Hess3,4
1Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Ulm, Head & Neck Cancer Center of the Comprehensive Cancer Center Ulm, Ulm, Germany.
头部和部状细胞癌 (HNSCC) 具有具有双重作用的B细胞. 调控性B (Breg) 细胞抑制免疫力,而三级淋巴体结构 (TLS) 中的B细胞对抗瘤,影响免疫疗法策略.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 癌症研究 癌症研究
背景情况:
- 在头支状细胞癌 (HNSCC) 中,明显的B细胞亚群表现出支持或抗瘤活动.
- 瘤微环境 (TME) 中的缺氧和细胞因子等因素影响B细胞功能,影响癌症的进展.
- 在TME内的调节性B (Breg) 细胞具有免疫抑制功能,分泌IL-10和TGF-β等细胞因子.
研究的目的:
- 在三级淋巴体结构 (TLS) 中,审查免疫抑制性布雷格细胞和免疫效应性B细胞之间的功能区别.
- 专注于这些B细胞子集在HNSCC瘤中的作用.
- 讨论针对瘤透B细胞 (TIL-B) 的当前免疫疗法.
主要方法:
- 文献综述侧重于HNSCC.中的B细胞亚群.
- 对B细胞在瘤微环境中的双重作用的分析.
- 在三级淋巴体结构 (TLS) 内的B细胞相互作用的检查.
主要成果:
- 布雷格细胞通过细胞因子和细胞接触抑制免疫反应.
- 成熟的TLS中的B细胞主要通过抗体依赖的细胞毒性和细胞化产生抗瘤作用.
- 有时,TLS可以容纳瘤细胞,这表明预后不佳.
结论:
- 瘤透B (TIL-B) 细胞表现出双向的免疫调节活性,是免疫治疗的目标.
- 了解效应体B细胞和布雷格细胞对于开发新型治疗方法至关重要.
- 向TIL-B细胞可以在HNSCC治疗中补充基于T细胞的免疫疗法.
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