林28调节胸膜生长和内置,并与胸膜上皮细胞中MHCII表达相关
Shiyun Xiao1, Wen Zhang1, Jie Li1
1Department of Genetics, University of Georgia, Athens, GA, United States.
Frontiers in immunology
|October 23, 2023
概括
林28通过控制MHCII表达和增殖来调节胸膜上皮细胞 (TEC) 的发育. 这项研究揭示了Lin28的存在.
科学领域:
- 免疫学 免疫学 免疫学
- 发展生物学 发展生物学
- 细胞生物学 细胞生物学
背景情况:
- 胸膜上皮细胞 (TECs) 对于T细胞发育至关重要.
- 对于TEC差异化的机制还没有完全理解.
- 林28在TEC中的作用基本上是未知的.
研究的目的:
- 研究TEC中Lin28的表达和功能.
- 确定林28对TEC差异化和扩散的影响.
- 在TEC中探索Lin28,Let-7g,FOXN1和MHCII之间的关系.
主要方法:
- 在胎儿和产后TEC中检查了Lin28和Let-7g的表达.
- 在TEC中利用了Lin28a和Lin28b的遗传删除.
- 在TEC中过度表达的Lin28a.
- 与FOXN1和MHCII水平相关的基因表达.
主要成果:
- 林28b和Let-7g显示了与MHCII水平相关的对立表达模式.
- Lin28a/b的TEC特异性删除减少了MHCII表达和TEC数量.
- 林28a过度表达增加了TEC和胸细胞数量,通过促进MHCIIlo TEC的增殖.
- Lin28和Let-7g的表达部分取决于FOXN1.1.
结论:
- 在TEC的发展和差异化中,Lin28起着至关重要的作用.
- 林28在胸膜本体生殖和卷发过程中调节MHCII表达和TEC增殖.
- 在编排TEC分化过程中,Lin28具有重要意义.
相关概念视频
Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
Receptor Downregulation in MVBs
2.1K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
2.1K
T Cell Activation and Clonal Selection
764
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
764
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K


