在胃肠道癌症中,三级淋巴状结构的预后价值
Aoyang Yu1, Menghan Cao1, Kaile Zhang1
1Department of Oncology, The Affiliated Hospital of Xuzhou Medical University, Jiangsu, China.
Frontiers in immunology
|October 23, 2023
概括
三级淋巴体结构 (TLS) 在对抗瘤方面至关重要. 胃肠道癌症中高TLS的存在预测了更好的存活率和对免疫治疗的反应,表明它们作为预后生物标志物的潜力.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 三级淋巴体结构 (TLS) 越来越多地被认为是它们在各种癌症中对抗瘤免疫力的作用.
- 然而,它们在胃肠道 (GI) 癌症的预后意义仍然不清楚,需要进一步调查.
研究的目的:
- 在胃肠道 (GI) 癌症中研究三级淋巴状结构 (TLS) 的预后价值.
- 为了确定TLS存在与患者的存活率和GI恶性瘤的治疗反应是否相关.
主要方法:
- 进行了系统的元分析,搜索主要的科学数据库 (科学网,PubMed,Embase,Cochrane图书馆) 到2023年5月1日.
- 包括的研究提供了TLS和患者结果的危险比率 (HR) 和95%置信区间 (CI).
- 使用TCGA数据库数据的生物信息学分析补充了元分析结果.
主要成果:
- 对32项研究 (5778名患者) 的分析显示,高TLS存在与显著延长的整体存活率 (OS),无复发存活率 (RFS),无疾病存活率 (DFS) 和无进展存活率 (PFS) 相关.
- 在接受免疫治疗的患者中,高TLS与改善的OS和PFS有关.
- 亚组分析表明,TLS和OS在结直肠癌 (CRC) 中没有显著的关联,并且在使用"Present"作为切线时,在肝细胞癌 (HCC) 中没有显著的相关性.
结论:
- 三级淋巴体结构代表了胃肠道癌症的显著预后预测因素.
- 作为一个有价值的预后生物标志物,TLS是有前途的,特别是在接受免疫治疗的患者中.
更多相关视频
07:32Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
Published on: April 12, 2024
1.4K
07:16Three-Dimensional Imaging of Tumor-Bearing Tissue Using the Iterative Bleaching Extends Multiplexity Approach
Published on: April 25, 2025
229
相关概念视频
01:15Secondary Lymphoid Organs
1.6K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
1.6K
01:18Lymphoid Cells and Tissues
1.2K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
1.2K
01:16Primary Lymphoid Organs
1.6K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
1.6K