队列概况:都灵前列腺癌预后 (TPCP) 队列
Nicolas Destefanis1, Valentina Fiano1, Lorenzo Milani1
1Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy.
Frontiers in oncology
|October 23, 2023
概括
图林前列腺癌预测队列 (TPCP) 是一项意大利研究,追踪891名患者以改善前列腺癌 (PCa) 预测. 结果将有助于更好的临床决策PCa管理.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 流行病学 流行病学
背景情况:
- 前列腺癌 (PCa) 是欧洲男性的主要癌症,临床行为各异.
- 准确的预后对于有效的PCa治疗策略至关重要.
- 现有的模型需要加强,以改善患者管理.
研究的目的:
- 引入都灵前列腺癌预测队列 (TPCP),这是意大利PCa研究的资源.
- 详细说明队列的特征,并确定其用于更新预后模型的实用性.
- 促进使用综合多模式数据开发新的预测模型.
主要方法:
- 在意大利都灵建立了891名非转移性PCa患者 (2008-2013) 的回顾性活检队列.
- 收集的临床数据,组织病理学,瘤DNA甲基化和数字幻灯片成像功能.
- 利用集中式泌尿病理学审查和数字病理学软件进行标准化分析.
主要成果:
- 随访时间中位数为10年,主要结果是转移,次要结果是PCa死亡和整体死亡率.
- 97名患者发生转移性疾病;301人死亡,其中56人死于PCa.
- 年龄和临床阶段 (cT1-cT3) 与转移性进展有显著的相关性,老年患者和晚期患者的发病率更高.
结论:
- 在意大利人口中,TPCP队列是完善现有的PCa预后模型的宝贵资源.
- 综合多模式数据 (病原体,数字,分子) 将使新的预后标志物发现成为可能.
- 这项研究旨在加强临床决策,以实现个性化的PCa患者管理.
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