相关实验视频
Updated: Jul 12, 2025
08:51
Human Egg Maturity Assessment and Its Clinical Application
Published on: August 19, 2019
19.3K
在高不成熟卵细胞率的预期正常反应者中,最终卵细胞成熟的双重触发因素:一个随机对照试验
Meng-Han Yan1, Zhen-Gao Sun1,2, Jing-Yan Song1,2
1The First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Frontiers in medicine
|October 23, 2023
概括
双触发可显著改善卵细胞成熟,怀孕和活产率,与单独的人类胆固醇激素 (hCG) 触发相比,女性的成熟率较低. 这种生育治疗提高了生殖结果.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 辅助生殖技术 辅助生殖技术
背景情况:
- 接受体外受精 (IVF) 的女性可能会经历低卵细胞成熟率,影响治疗成功.
- 常规的排卵诱导协议经常使用人类胆性腺激素 (hCG) 触发剂,这可能对某些患者群体来说是不理想的.
研究的目的:
- 为了比较双触发策略与标准hCG触发器在改善生殖结果方面的有效性.
- 为了具体评估女性的结果,有>50%未成熟卵子细胞的历史.
主要方法:
- 一项前性研究涉及73名40岁以下的女性,她们的未成熟卵细胞数量很高.
- 患者被随机分配,接受hCG触发剂或双触发剂 (淋巴激素释放激素 (GnRH) 激动剂和hCG).
- 卵细胞成熟率是主要终点,并评估了累积怀孕和活产率.
主要成果:
- 双触发组表现出明显更高的卵细胞成熟率 (84.0%对比55.5%,p < 0.001).
- 累积怀孕率 (69.4%vs. 40.0%,p=0.035) 和活产率 (66.7%vs. 36.0%,p=0.022) 也在双触发器下显著改善.
- 两组之间没有观察到卵细胞产量的显著差异.
结论:
- 对于卵细胞成熟率低的女性来说,双触发疗法比单独使用hCG更有效.
- 这一策略为这一特定患者群体的试管婴儿成功率提供了潜在的改善.
相关概念视频
02:07Oogenesis
63.8K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.8K
01:27Ovarian Cycle
1.3K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.3K
01:30Hormonal Control of the Ovarian Cycle
538
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
538
01:57Meiosis II
183.5K
Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...
183.5K
01:20Folliculogenesis
821
Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...
821