在膀癌中家庭风险和与吸烟和酒精消费的相互作用:基于人口的队列研究
Hyun Jung Kim1, Kyoung-Hoon Kim2, Sung Won Lee3
1Department of Preventive Medicine, College of Medicine, Korea University, Seoul 02841, Korea.
World journal of oncology
|October 23, 2023
概括
患有膀癌家族史的人面临更高的风险,特别是与吸烟相结合时. 遗传倾向是关键因素,突出了对高风险群体需要遗传咨询的需求.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 遗传因素与膀癌的发展有关,但人口层面的家族风险数据有限.
- 了解家族聚合对于风险分层和预防策略至关重要.
研究的目的:
- 为了量化膀癌的家族风险.
- 调查膀癌家族病史与吸烟和饮酒等生活方式因素之间的相互作用.
主要方法:
- 一项大型队列研究 (5,524,403名受试者) 使用国家医疗保险数据库 (2002-2019).
- 为了评估家族风险,计算了危险比率 (HR) 和95%置信区间 (CI).
- 由于相互作用而导致的相对过度风险 (RERI) 用于评估基因环境相互作用.
主要成果:
- 患有患病父母的后代患膀癌的风险增加了2.09倍.
- 积极的家族病史与吸烟相结合显著增加疾病风险 (HR:3.60),具有统计学意义的相互作用 (RERI:0.72).
- 家庭病史也增加了酒精消费者的风险,尽管这种相互作用在统计学上没有显著意义.
结论:
- 遗传倾向似乎是家族膀癌聚集的主要驱动因素.
- 吸烟者和有膀癌家族史的酒精消费者是高危人群.
- 对于具有家族病史和相关生活方式风险因素的个人,建议进行遗传咨询.
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