在神经性食欲症中,半球间功能性同位素连接和体微观结构的改变
Yiling Wang1, Lirong Tang2, Miao Wang3
1Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Quantitative imaging in medicine and surgery
|October 23, 2023
概括
神经性饮食 (BN) 显示大脑连接性发生变化,脑体 (CC) 微观结构下降,特定区域的同位素功能连接性增加. 这些神经变化可能是独立的,并与奖励和自我感知途径相关联.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 神经性吃 (BN) 与不适应的神经相互作用有关.
- 半球间的通信,由体 (CC) 介导,在BN中理解得很差.
研究的目的:
- 调查BN中半球间同位素功能连接的变化.
- 在BN患者中探索体微观结构 (CC) 的变化.
主要方法:
- 磁共振成像 (MRI) 用于比较42名BN患者和38名健康对照 (HCs).
- 分析了voxel镜像同位素连接 (VMHC) 和CC白质微观结构.
- 基于种子的功能连接 (FC) 和相关性分析检查了成像变量和临床特征之间的关系.
主要成果:
- 在BN患者中,中部CC的分数异构性 (FA) 降低,轨道前皮层 (OFC) 和中部回 (MTG) 的VMHC增加.
- 在双边OFC,MTG和其他大脑区域之间观察到超连接性.
- VMHC和CC微观结构的变化没有直接相关,这表明独立性.
结论:
- 在BN中存在异常的半球间功能连接和CC微观结构.
- 这些神经变化可能彼此独立.
- 在BN中的超连接性涉及与奖励,身体形象和自我参考相关的区域.
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