非肝血清氨水平与败血症相关脑病变之间的关系:一项回顾性队列研究
Pei Wang1, Jia Yan1, Qiqing Shi2
1Department of Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China.
Emergency medicine international
|October 23, 2023
概括
升高的非肝血清氨水平 (≥45μmol/L) 是败血症相关脑病变 (SAE) 的独立风险因素. 对败血症患者来说,对氨的监测至关重要,以预测SAE发生率和死亡率.
科学领域:
- 关键护理医学 关键护理医学
- 神经学 神经学
- 毒理学 毒理学 毒理学
背景情况:
- 非肝性高血是常见的败血症.
- 氨被认为是肝脏脑病变的原因.
- 非肝脏氨和败血症相关脑病变 (SAE) 之间的联系还不清楚.
研究的目的:
- 为了研究血清氨水平和SAE在患有败血症的重症成人患者之间的关联.
- 为了确定可预测SAE的血清氨值.
- 探索氨对SAE严重性和死亡率的影响.
主要方法:
- 从MIMIC IV数据库 (2008-2019) 中回顾分析数据.
- 包括患有败血症的重症成人患者,但不包括患有肝病的患者.
- 统计分析以确定血清氨含量与SAE之间的关联,并根据混因素进行调整.
主要成果:
- 在720名败血症患者中,SAE发生率很高 (64.6%).
- 血清氨≥45μmol/L是SAE的一个独立风险因素 (OR:3.508,p < 0.001).
- 较高的氨水平与增加的医院死亡率和在SAE患者中较高的SOFA分数相关.
结论:
- 非肝血清氨水平≥45μmol/L显著增加SAE风险.
- 对于败血症患者,建议对血清氨的密切监测.
- 氨水平可以作为SAE严重程度和预后的生物标志物.
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