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一项关于HPV感染预后与宫结合后病变复发之间的相关性研究

Junling Lu¹, Shichao Han¹, Ya Li¹

¹Department of Gynecology and Obstetrics, Second Affiliated Hospital of Dalian Medical University, Dalian, China.

Frontiers in microbiology

|October 23, 2023

概括

持续的人类乳头瘤病毒 (HPV) 感染与子宫癌复发有关. 诸如年龄,怀孕史,吸烟和一致的HPV基因型等因素在手术后增加复发风险,需要对高风险患者进行个性化随访.

科学领域:

妇科妇科妇科妇科
在瘤学瘤学.
病毒学病毒学

背景情况:

持续的人类乳头瘤病毒 (HPV) 感染是导致宫癌发展的关键因素.
状内皮层病变 (SIL) 或宫内皮层瘤 (CIN) 是宫癌的前体.
高度SIL (HSIL) 的局部治疗可以有效地预防癌症的进展.

研究的目的:

为了识别容易出现宫病变复发的高风险患者.
调查宫病变的复发和手术后HPV感染回归之间的关系.
确定与子宫病变复发相关的其他风险因素.

主要方法:

对300名HSIL患者的临床数据的回顾性分析.
从大连医科大学第二附属医院 (2019-2020) 治疗的患者收集的数据.
调查的重点是HPV感染状况,病变复发以及患者的人口统计/病史.

主要成果:

治疗后6个月,12个月和24个月,HPV阴性率分别为81.81%,85.71%和90.91%.
平均病变复发率为8.16%,中位复发时间为14个月.
感染HPV16的风险最高;61岁以上的患者HPV阴性率较低;多种HPV基因型和不同的手术前/后基因型与复发率较低有关.

结论:

患者年龄≥50岁,有≥3次怀孕,吸烟史,和一致的HPV基因型前/后结合,有更高的复发风险.
这些因素可能表明HPV再感染增加或持续感染.
对于高风险患者来说,个性化后续和管理至关重要,以减少复发和预防宫癌.

关键词:

感染的HPV感染的HPV感染.宫 ?? 缩的发生宫病变是指宫病变的发生.预后预后预后复发性复发性复发性

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