在异质批量和连续流量条件下使用酶性氧化合成生物可再生烯单体的合成
Arianna Brandolese1, David H Lamparelli1, Miquel A Pericàs1,2
1Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute for Science & Technology (BIST), Av. Països Catalans 16, 43007 Tarragona, Spain.
ACS sustainable chemistry & engineering
|October 23, 2023
概括
这项研究提出了一种使用Novozym 435和过氧化 (H2O2) 的可持续环氧化方法. 该工艺在批量和连续流系统中都有效,用于生产烯环氧化物和功能化聚合物.
科学领域:
- 绿色化学 绿色化学
- 生物催化剂是一种生物催化剂.
- 聚合物科学 聚合物科学
背景情况:
- 酶性环氧化为传统方法提供了一个可持续的替代方案.
- 在Novozym 435上固定的Candida antarctica的脂酶B是一种强大的生物催化剂.
- 过氧化 (H2O2) 作为一种对环境无害的氧化剂.
研究的目的:
- 开发和优化生物可再生烯的可持续环氧化协议.
- 在批量和连续流条件下调查本协议的应用.
- 为了证明催化剂的可回收性和方法的可扩展性.
主要方法:
- 使用固定式B脂酶 (Novozym 435) 作为生物催化剂.
- 使用过氧化 (H2O2) 作为环氧化反应的氧化剂.
- 在异质批量和连续流反应堆设置中进行实验.
主要成果:
- 在批量模式下,Novozym 435催化剂在10个周期内表现出高活性和可回收性.
- 连续流量运行维持了催化剂的生产率超过30小时.
- 成功地生产了各种烯环氧化物的克数量.
- 该协议已成功应用于具有环氧基团的生物基聚合物后功能化.
结论:
- 使用H2O2和Novozym 435建立了一种实用,安全和可持续的流体环氧化方法.
- 这种方法可以有效地生产烯环氧化物和生物聚合物的功能化.
- 这些发现支持使用生物催化剂用于更绿色的化学合成和聚合物修饰.
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