铁聚L的化合物的抗菌活性
Mohammed Arafat Mohammed1, Younis Saadi Saeed1, Jassim Fatehi Ali1
1Department of Biology, College of Education for Pure Sciences, University of Mosul, Mosul, Iraq.
Pakistan journal of pharmaceutical sciences
|October 23, 2023
概括
铁聚L.叶子提取物产生具有显著抗菌性能的化合物. 这些天然化合物证明了对格拉姆阳性和格拉姆阴性细菌的有效性,突出了植物的治疗潜力.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 自然产品化学 自然产品化学
背景情况:
- Teucrium polium L. (Lamiaceae家族) 是一种具有潜在药用应用的植物.
- 化合物以其多样化的生物活性而闻名,包括抗菌作用.
- 识别新的天然抗菌剂对于打击抗生素耐药性至关重要.
研究的目的:
- 从Teucrium polium L.叶片提取物中分离和识别化合物.
- 评估与各种细菌菌株对抗分离的化合物的抗菌活性.
主要方法:
- 使用,乙烯酸乙烯和乙醇对Teucrium polium L.叶子进行序列提取.
- 使用柱状染色学 (CC),薄层染色学 (TLC) 和高性能液态染色学 (HPLC) 隔离和净化化合物.
- 使用磁盘扩散试验对黄金葡萄球菌 (格拉姆阳性) 和沙门氏菌,Pseudomonas aeruginosa,Klebsiella pneumoniae和大肠杆菌 (格拉姆阴性) 的抗菌活性评估.
主要成果:
- 他们分离出了三种不同的基分离物,分别是4-基酸,甲基醇和酸.
- 分数F1表现出针对K. pneumoniae,P. aeruginosa和S. aureus的显著抑制区 (19-21毫米).
- 分数F2表现出广泛的活性,抑制区为19-23毫米,针对所有测试的细菌菌株.
结论:
- 铁聚L是一种丰富的化合物来源,具有强大的抗菌活性.
- 隔离的化合物,特别是F2部分,显示出作为传统抗生素的天然替代品的希望.
- 对Teucrium polium L.的进一步研究可能会导致开发新的抗菌剂.
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