用于避孕和更年期障碍的以纳米粒子为基础的乙inyl estradiol 透皮药物递送系统的配方和特征
Asma Afzal1, Khadija Zaman1, Mahpara Tabassum1
1Institute of Pharmaceutical Sciences, University of Veterinary and Animals Sciences, Lahore, Pakistan.
Pakistan journal of pharmaceutical sciences
|October 23, 2023
概括
这项研究在通过皮肤递送药物系统 (TDDS) 中开发了乙雌激醇 (EE) 纳米颗粒,以减少口服避孕药的副作用. 新型贴片提供持续的药物释放,改善患者的服药性和治疗结果.
科学领域:
- 药品制造 药品制造 药品制造
- 材料科学 材料科学 材料科学
背景情况:
- 口服避孕药可以引起不良影响.
- 通过皮肤递送药物系统 (TDDS) 为药物管理提供了替代方案.
研究的目的:
- 开发用于穿皮贴片的乙烯基雌激醇 (EE) 纳米颗粒.
- 为了实现持续的药物释放,并减少剂量频率,以改善避孕.
主要方法:
- 使用溶剂蒸发方法制备了带EE的奇托桑纳米颗粒.
- 纳米粒子的特点是尺寸,形态,产量和捕获效率.
- 通过皮肤贴片被制造和评估物理特性,药物含量,体外释放和体外透.
主要成果:
- 开发的补丁是透明的,具有均的表面和最佳的灵活性.
- 在体外释放研究显示持续扩散控制释放,其中一种配方 (F1) 在72小时内释放97.6%.
- FTIR和DSC分析证实没有药物辅助剂相互作用,稳定性研究表明该产品是稳定的.
结论:
- 将EE纳米颗粒纳入皮肤贴片中,为口服避孕药提供了可行的替代方案.
- 这种TDDS方法通过降低剂量频率和持续的治疗药物释放来提高患者的服药性.
更多相关视频
相关概念视频
Drug Delivery: Overview
300
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
300
Drug Delivery: Miscellaneous Routes
359
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
359
Drug Delivery: Enteral Route
468
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
468
Birth Control Methods
292
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
292
Hormonal Regulation of the Menstrual Cycle
408
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
408
Menopause
175
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
175


