在FGF7基因中的新型22-bp InDel与山羊的生长特征有显著的关联
Xian-Feng Wu1, Yuan Liu1, Ying-Gang Wang2
1Fujian Academy of Agricultural Sciences, Fuzhou, Fujian, China.
Animal biotechnology
|October 23, 2023
概括
纤维细胞生长因子7 (FGF7) 基因中的新的22-bp InDel多态性与山羊的生长特征有关. 与DD基因型相比,ID或II基因型的山羊表现出优异的生长,这表明FGF7是育种计划的标志物.
科学领域:
- 动物遗传学动物遗传学
- 分子生物学分子生物学
- 畜牧科学 畜牧科学 畜牧科学
背景情况:
- 纤维细胞生长因子7 (FGF7) 在脂质代谢中起作用,是肌肉发育的候选基因.
- 关于FGF7基因与山羊生长特征之间的关联的研究有限.
研究的目的:
- 调查FGF7基因中的新型InDel多态性和山羊的生长特征之间的关联.
- 分析各种山羊组织中的FGF7mRNA表达水平.
主要方法:
- 在六个成年山羊组织中量化了FGF7mRNA表达.
- 在3个品种的396只山羊中发现了22bp的InDel多态,并对其进行了基因定型.
- 进行了相关性分析,以评估基因型与生长特征之间的关联.
主要成果:
- FGF7基因表达在脂肪组织中最高,这表明它在脂肪沉积中的作用.
- 在FGF7中22bp的InDel多态化导致了三种基因型:II,ID和DD.
- InDel多态性与生长特征有显著的相关性 (P < 0.05).
结论:
- 与DD基因型相比,具有ID和II基因型的山羊表现出优越的生长性能.
- 在FGF7基因中发现的22-bp InDel可以作为一种有价值的分子标记物,用于在育种计划中增强山羊生长特征.
相关概念视频
00:53Transgenic Organisms
31.2K
Overview
31.2K
01:49Multiple Allele Traits
34.3K
The Concept of Multiple Allelism
34.3K
01:19X-linked Traits
55.0K
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
55.0K
01:33Pleiotropy
40.5K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
40.5K
02:11Reporter Genes
11.4K
Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
11.4K
01:05Single Nucleotide Polymorphisms-SNPs
15.2K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.2K