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抗生素用于儿童中耳炎与输液 (OME) 的治疗
Caroline A Mulvaney1, Kevin Galbraith1, Katie E Webster1
1Cochrane ENT, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
口服抗生素对患有输液性中耳炎 (OME) 的儿童具有非常不确定的益处. 虽然它们可能会略微减少OME的持续性,但对听力和长期影响的影响仍然不清楚.
科学领域:
- 儿科耳鼻喉科 儿科耳鼻喉科
- 基于证据的医学基于证据的医学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 带出血的中耳炎 (OME) 在幼儿中很常见,可能导致听力损失和发育问题.
- 管理策略包括警等待,自膨胀和医疗/手术治疗.
- 抗生素有时用于OME以解决细菌存在或生物膜.
研究的目的:
- 评估口服抗生素治疗儿童OME的益处和危害.
- 评估对听力,生活质量和不良事件的影响.
主要方法:
- 随机和准随机对照试验的系统审查和元分析.
- 包括6个月至12岁的有OME的儿童.
- 与安慰剂或没有治疗的口服抗生素进行比较,重点关注主要结果:听力,生活质量和过敏反应.
主要成果:
- 包括19项研究 (2581名参与者),评估各种口服抗生素.
- 抗生素与安慰剂:非常不确定的证据表明在听力恢复方面存在潜在的益处,但OME持久性数据也是不确定的.
- 抗生素与不治疗:低确定性证据表明,OME持续时间可能略有减少,长达三个月;听力影响不确定.
结论:
- 在OME中使用抗生素的证据确定性低至非常低.
- 抗生素可能为OME解决提供轻微的短期益处,但对听力有不确定的影响.
- 长期影响和危害尚不清楚,需要仔细考虑自发解决率.
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