Jove
Visualize
联系我们

相关概念视频

Peptide Bonds02:43

Peptide Bonds

74.6K
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
74.6K
Peptidoglycan Synthesis01:28

Peptidoglycan Synthesis

22
Structure of PeptidoglycanPeptidoglycan is a vital structural component of the bacterial cell wall, providing mechanical strength and shape to the cell. It consists of repeating units of two sugars—N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM)—linked by β-1,4 glycosidic bonds. These sugar chains are cross-linked by short peptide chains, forming a mesh-like polymer that surrounds the bacterial plasma membrane.Cytoplasmic Phase – Precursor SynthesisPeptidoglycan...
22
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

2.5K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
2.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Generation of membrane-permeable cyclic peptides inhibiting protein-protein interaction.

Nature chemical biology·2026
Same author

Yeast Display Technology Enables Rapid Discovery of Low-Nanomolar Macrocyclic Peptide Inhibitors of Human Angiotensin-Converting Enzyme 2.

Journal of medicinal chemistry·2026
Same author

Ligand-Directed Site-Selective Cysteine Bioconjugation of the KELCH Domain of KEAP1 with Hypervalent Iodine Reagents.

Journal of the American Chemical Society·2025
Same author

Screening macrocyclic peptide libraries by yeast display allows control of selection process and affinity ranking.

Nature communications·2025
Same author

Phage Display Selection against a Mixture of Protein Targets.

ACS chemical biology·2025
Same author

Structure-Affinity Relationship Analysis and Affinity Maturation of a Calprotectin-Binding Peptide.

Chembiochem : a European journal of chemical biology·2025
Same journal

Selective Degradation of Polyurethanes in Mixed Plastic Wastes via Ir-Catalyzed Hydrogenolysis.

Angewandte Chemie (International ed. in English)·2026
Same journal

Covalent Organic Framework Photocatalysts: Decoding Linkage Chemistry in Hydrogen Peroxide Synthesis From Air and Water.

Angewandte Chemie (International ed. in English)·2026
Same journal

Anomeric Amide Enabled Divergent Synthesis of Unsymmetrical Ureas, Carbamates, Thioesters, and Amides From Aldehydes.

Angewandte Chemie (International ed. in English)·2026
Same journal

Anisotropic Magneto-Chiral Dichroism in Lanthanide Complexes.

Angewandte Chemie (International ed. in English)·2026
Same journal

Engineering LE-CT State Synergy in Aminoboranes for Single Molecule White Light Emission and Dual-Mode Chiroptical/Phosphorescence Output.

Angewandte Chemie (International ed. in English)·2026
Same journal

Editable Hydrogen Bond Network Within the Electric Double Layer for CO<sub>2</sub> Reduction.

Angewandte Chemie (International ed. in English)·2026
查看所有相关文章
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jul 12, 2025

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

11.9K

用于药物开发的循环.

Xinjian Ji1, Alexander L Nielsen1, Christian Heinis1

  • 1Institute of Chemical Sciences and Engineering, School of Basic Sciences, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.

Angewandte Chemie (International ed. in English)
|October 23, 2023
PubMed
概括
此摘要是机器生成的。

在自然界中丰富的循环,越来越多地使用先进技术开发成药物. 本次审查强调了它们的治疗潜力,技术进步以及未满足的医疗需求的未来机会.

关键词:
循环是一种循环.宏观循环是一个宏观循环.这是一种类.类药物 药物 类药物类治疗药物 类治疗药物

更多相关视频

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

2.7K
Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
10:12

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

2.1K

相关实验视频

Last Updated: Jul 12, 2025

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

11.9K
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

2.7K
Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
10:12

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

2.1K

科学领域:

  • 生物化学和药物化学 医学化学
  • 药物发现和开发 药物发现和开发

背景情况:

  • 循环是一种多功能分子,具有多种应用,包括治疗,研究工具和食品添加剂.
  • 最近合成和药物开发的进步导致每年大约有一种循环药物的一致批准率.
  • 选类库和de novo配体生成的新兴技术有助于开发独立于自然来源的循环类药物.

研究的目的:

  • 审查治疗相关的循环,强调那些来自自然来源的.
  • 讨论循环的独特的物理化学和生物特性.
  • 探索循环联体开发的最新技术创新,并确定解决未满足医疗需求的未来机会.

主要方法:

  • 对具有治疗意义的天然和合成循环的文献综述.
  • 分析合成,选和设计方面的技术进步.
  • 讨论案例研究和成功循环药物开发的例子.

主要成果:

  • 循环具有独特的特性,使其成为有吸引力的药物候选者.
  • 技术进步显著扩大了开发新型循环疗法的范围.
  • 该领域为开发循环来治疗未满足医疗需求的疾病提供了许多机会.

结论:

  • 循环代表了一类重要的,不断增长的治疗剂.
  • 类技术的持续创新有望释放循环类药物的进一步潜力.
  • 通过循环开发来解决未满足的医疗需求仍然是该领域的重点.