用于药物开发的循环
Xinjian Ji1, Alexander L Nielsen1, Christian Heinis1
1Institute of Chemical Sciences and Engineering, School of Basic Sciences, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.
Angewandte Chemie (International ed. in English)
|October 23, 2023
概括
在自然界中丰富的循环,越来越多地使用先进技术开发成药物. 本次审查强调了它们的治疗潜力,技术进步以及未满足的医疗需求的未来机会.
科学领域:
- 生物化学和药物化学 医学化学
- 药物发现和开发 药物发现和开发
背景情况:
- 循环是一种多功能分子,具有多种应用,包括治疗,研究工具和食品添加剂.
- 最近合成和药物开发的进步导致每年大约有一种循环药物的一致批准率.
- 选类库和de novo配体生成的新兴技术有助于开发独立于自然来源的循环类药物.
研究的目的:
- 审查治疗相关的循环,强调那些来自自然来源的.
- 讨论循环的独特的物理化学和生物特性.
- 探索循环联体开发的最新技术创新,并确定解决未满足医疗需求的未来机会.
主要方法:
- 对具有治疗意义的天然和合成循环的文献综述.
- 分析合成,选和设计方面的技术进步.
- 讨论案例研究和成功循环药物开发的例子.
主要成果:
- 循环具有独特的特性,使其成为有吸引力的药物候选者.
- 技术进步显著扩大了开发新型循环疗法的范围.
- 该领域为开发循环来治疗未满足医疗需求的疾病提供了许多机会.
结论:
- 循环代表了一类重要的,不断增长的治疗剂.
- 类技术的持续创新有望释放循环类药物的进一步潜力.
- 通过循环开发来解决未满足的医疗需求仍然是该领域的重点.
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