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Updated: Jul 12, 2025

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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尼科米Sz和尼科米Soz的总合成

Shuai Fan1, Tai Jiang1, Muhammad Nasir Siddique1

  • 1State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.

Organic letters
|October 23, 2023
PubMed
概括

研究人员开发了一种高效的合成nickkomycins Sz/Soz,锁定核酸抗生素. 这种方法克服了创建这些复杂分子的关键挑战,使其能够进一步研究它们的潜在应用.

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Combined Effects of Drugs: Synergism01:27

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Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
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