相关实验视频

Updated: Jul 12, 2025

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase

Published on: April 23, 2019

M2OR:嗅觉受体-气味剂对的数据库,以了解嗅觉的分子机制

Maxence Lalis¹, Matej Hladiš¹, Samar Abi Khalil¹

¹Institut de Chimie de Nice, Université Côte d'Azur, UMR 7272 CNRS, 06108 Nice, France.

Nucleic acids research

|October 23, 2023

概括

M2OR数据库提供了对嗅觉受体 (OR) 和分子相互作用的精选数据,编制了75,050个生物测试. 该资源有助于研究人员了解复杂的分子识别谱的气味.

科学领域:

神经科学是一个神经科学.
生物化学生物化学
生物信息学是一种生物信息学.

背景情况:

哺乳动物的嗅觉依赖于与气味分子相互作用的嗅觉受体 (ORs).
了解ORs的特定分子识别光谱是一个重大的科学挑战.
感官神经元上的嗅觉受体 (ORs) 通过复杂的激活模式编码不同的气味.

研究的目的:

介绍分子到嗅觉受体 (M2OR) 数据库,这是一个对OR分子相互作用的精心策划的资源.
为了促进对有关OR气味剂识别的当前研究环境的探索.
为研究嗅觉的组合代码提供一个全面的数据集.

主要方法:

从文献和公共数据库中编制了75,050个生物测试实验,用于51,395个不同的OR分子对.
关于OR反应,分子相互作用,受体序列和实验条件的综合数据.
开发了先进的搜索功能,包括批量查询和按物种和测试系统等元数据进行过.

主要成果:

现在,M2OR数据库包含了有关嗅觉受体分子相互作用的大量精选数据.
用户可以查询分子活动的数据库,识别特定OR的激动剂,并探索OR反应模式.
该数据库提供了基于实验数据的二元组合嗅觉代码.

结论:

M2OR是嗅觉研究的宝贵,集中资源,简化了对复杂相互作用数据的访问.
该数据库使研究人员能够研究气味的分子基础,并开发预测模型.
有助于更深入地了解臭味感知背后的复杂激活模式.

更多相关视频

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity

Published on: June 2, 2014

Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay

Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay

Published on: October 2, 2017

相关概念视频

Olfaction

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...

Olfactory Receptors: Location and Structure

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...

Physiology of Smell and Olfactory Pathway

Physiology of Smell and Olfactory Pathway

Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...