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Updated: May 27, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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选择性向平行G-四重复结构使用L-RNA合酶.

Danyang Ji1, Jia-Hao Yuan2, Shuo-Bin Chen2

  • 1Department of Chemistry and State Key Laboratory of Marine Pollution, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, China.

Nucleic acids research
|October 23, 2023
PubMed
概括

研究人员开发了一种新的方法,G4-SELEX-Seq,以创建L-RNA体. 体L-Apt12-6特别针对平行G-四重复体 (G4),提供治疗潜力和基因调节的工具.

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RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...