脂肪组织分布,细胞形态和功能的变化标志着年轻人肥胖的主要胰岛素过分分泌
Domenico Tricò1,2, Martina Chiriacò1,2, Jessica Nouws3
1Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Diabetes
|October 23, 2023
概括
青少年初级胰岛素过分分泌与明显的脂肪组织变化和较高的葡萄糖不耐症风险有关. 了解这种脂肪-岛屿交叉是识别那些有肥胖和代谢功能障碍风险的人的关键.
科学领域:
- 代谢研究的研究.
- 内分泌学 在内分泌学.
- 脂肪组织生物学 脂肪组织生物学
背景情况:
- 主要的胰岛素过分分泌,独立于胰岛素抵抗,与肥胖和代谢健康不佳有关.
- 脂肪组织和胰腺β细胞之间的相互作用是复杂的,并影响代谢结果.
研究的目的:
- 为了研究患有原发性胰岛素高分泌的青少年脂肪组织特征.
- 分析由脂肪岛轴影响的纵向代谢变化.
主要方法:
- 患有肥胖 (没有糖尿病) 的青少年的多民族队列.
- 评估β细胞功能,葡萄糖耐受性,人体成分 (MRI),脂肪细胞大小和体内脂质周转率 (2H2O标记).
- 2年的随访时间,以追踪代谢变化.
主要成果:
- 超分泌者表现出增强的β细胞葡萄糖敏感性,但较差的葡萄糖耐受性,尽管类似的整体脂肪和胰岛素耐药性.
- 在高分泌者中观察到更大的内脏和肝脏内脂肪,更大的皮下脂肪细胞,更高的瘦素/脂肪质量和更快的脂质周转率.
- 超分泌者增加了脂肪积累,并在2年内增加了3倍的异常葡萄糖耐受性风险.
结论:
- 主要胰岛素过分分泌与特定的脂肪组织变化 (分布,细胞性,脂质动态) 相关,独立于整体肥胖和胰岛素抵抗.
- 脂肪-岛屿交叉对代谢健康起着至关重要的作用.
- 识别具有改变脂肪岛动态的个体可能有助于预测高胰岛素血症,体重增加和葡萄糖不耐受性的风险.
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