相关实验视频
Updated: Jul 12, 2025
04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
1.7K
内源性和外源性甲状腺毒性以及老年人发生认知障碍的风险
Roy Adams1, Esther S Oh1,2, Sevil Yasar2
1Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
JAMA internal medicine
|October 23, 2023
概括
甲状腺毒性病,包括甲状腺激素的过度治疗,与老年人认知障碍的风险更高有关. 这强调了谨慎的甲状腺激素处方的重要性,以防止潜在的认知衰退.
科学领域:
- 内分泌学 在内分泌学.
- 老年医学 老年医学
- 神经学 神经学
背景情况:
- 甲状腺激素是一种常见的处方,高达20%的患者可能被过度治疗.
- 内源性甲状腺功能障碍是痴呆症的已知危险因素,但对阳性甲状腺毒性病的数据有限.
研究的目的:
- 调查甲状腺毒性病 (内源性和外源性) 与认知障碍风险之间的关联.
- 评估甲状腺激素治疗的后果 - - 阳性甲状腺毒性病对认知健康的影响.
主要方法:
- 对65岁以上65931名患者电子健康记录的纵向分析.
- 随时间变化的分析确定了低甲状腺激素 (TSH) 水平作为暴露,按原因分类 (内源,外源,未知).
- 认知障碍 (轻度认知障碍,全因痴呆症) 是主要的结局指标.
主要成果:
- 与未暴露的患者 (6.4%) 相比,甲状腺毒素症患者的认知障碍发生率更高 (11.0%).
- 所有原因的甲状腺毒性病与认知障碍诊断的风险增加显著相关 (aHR,1.39).
- 特别是外源性甲状腺毒性,仍然是显著的风险因素 (aHR,1.34),有证据表明剂量与反应的关系.
结论:
- 低TSH水平,表明任何原因的甲状腺毒性病,与老年人发生认知障碍的风险更高有关.
- Iatrogenic 甲状腺毒性病,通常是甲状腺激素过度治疗的结果,是认知障碍的重要危险因素.
- 这些发现强调了指导甲状腺激素处方实践的必要性,以减轻与过度治疗和潜在认知衰退相关的风险.
相关概念视频
01:20Synthesis and Regulation of Thyroid Hormones
4.7K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.7K
01:18Functions of Thyroid Hormones
2.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.8K
01:30Cognitive Development During Adulthood
125
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
125
01:27Language and Cognition
354
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
354
01:26Aging
59
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
59
01:23The Thyroid Gland
3.9K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
3.9K