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针对瘤向蛋白质降解的生物正方位激活PROTAC的合理设计

Tao Bi1,2, Pan Liang1,2, Yanan Zhou1,2

  • 1National Traditional Chinese Medicine Clinical Research Base and Drug Research Center of the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Chunhui Road, Luzhou 646000, China.

Journal of medicinal chemistry
|October 23, 2023
PubMed
概括

生物正方位激活前药物 (BT-PROTACs) 提供了一种控制蛋白质降解的新方法. 这种策略使用一种可以在瘤组织中特别激活的前药物,减少全身毒性.

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