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抗素耐药的Acinetobacter baumannii和Klebsiellapneumoniae的风险因素和耐药性概况

Dipanshu Vasesi¹, Varsha Gupta¹, Parakriti Gupta¹

¹Department of Microbiology, GMCH-32, Chandigarh, India.

Indian journal of medical microbiology

|October 23, 2023

概括

北印度的抗卡巴胺细菌中正在出现胆固醇耐药性,内置设备和先前的抗生素使用是关键风险因素. 了解这种患病率对于制定有效的抗生素政策至关重要.

科学领域:

微生物学微生物学
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

抗菌素耐药性 (AMR) 是一个关键的全球健康挑战.
碳烯和胆固醇对治疗多药耐药性 (MDR) 克莱布西拉肺炎和阿辛托巴克特物种至关重要.
抗药性增加需要对胆固醇抗药性进行全面监测.

研究的目的:

为了确定抗卡巴因耐药分离物中胆素耐药性的流行率.
识别与胆固醇抗性相关的风险因素.
在印度北部的一家三级护理中心,对抗性基因进行了鉴定.

主要方法:

在1.5年内进行的前性病例控制研究.
包括所有耐卡巴因的克莱布西拉肺炎菌和Acinetobacter分离物.
柯比-尔盘扩散和汁微稀释用于胆固醇敏感性测试 (CLSI指南).
对blaNDM,blaKPC和blaOXA-48基因的基因型表征.

主要成果:

在103个 (6.8%) 抗卡巴烯姆分离物中,有7个显示出对胆固醇的耐药性.
常见的危险因素包括内置设备,先前的抗生素暴露和类固醇使用.
检测到 blaNDM 和 blaOXA-48 基因; blaKPC 缺席.
与病房相比,在ICU中观察到更高的抗药率.

结论:

这项研究强调了研究群体中抗素的发病率和风险因素.
这些发现有助于制定当地抗生素政策和感染控制战略.
基因型数据提供了对抗性机制的见解.

关键词:

这种细菌是Acinetobacter baumannii.碳烯的使用方法科里斯耐药性科里斯耐药性克莱布西拉肺炎是一种肺炎.风险因素风险因素

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