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可卡因使用严重程度和戒断对行为表现和抑制反应的神经过程的影响

Guangfei Li¹, Zhao Zhang², Yihe Zhang³

¹Department of Biomedical Engineering, Faculty of Environment and Life. Beijing University of Technology, Beijing, China; Beijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical Transformation, Beijing, China.

Psychiatry research. Neuroimaging

|October 23, 2023

概括

可卡因依赖会根据使用的严重程度和戒断的持续时间对反应抑制产生不同的影响. 上环中的神经活动调解这些效应,为成恢复提供了洞察力.

科学领域:

神经科学是一个神经科学.
成研究研究成研究
认知心理学认知心理学

背景情况:

以前的研究表明,可卡因成的反应抑制缺陷.
可卡因使用严重程度和戒断对这些缺陷的影响,以及它们的神经支,仍然在很大程度上未被探索.

研究的目的:

调查可卡因使用严重程度和戒断时间如何影响反应抑制.
确定神经机制,特别是在上旋环 (STG) 中,这些神经机制调解了可卡因依赖 (CD) 个体的这些效应.

主要方法:

在停止信号任务 (SST) 中使用功能磁共振成像 (fMRI) 在67名CD患者和84名健康对照 (HC) 中.
停止信号反应时间 (SSRT) 被计算为测量响应抑制.
全脑回归分析和中介/途径分析检查了多年可卡因使用 (YOC),戒断日 (DOA),SSRT和STG活动之间的关系.

主要成果:

在CD和HC组之间没有发现SSRT的显著差异.
在CD组中,YOC与SSRT (较差的抑制) 有正相关,而DOA与SSRT (更好的抑制) 有负相关.
双边的STG活动与两组的反应抑制有关,YOC和DOA通过CD中的STG活动影响了SSRT.

结论:

在可卡因成中,反应抑制因使用的严重程度和戒断的持续时间而受到调节.
上旋在调解可卡因使用严重程度和戒断对抑制反应的影响方面发挥着至关重要的作用.
这些发现提供了对可卡因依赖的认知恢复的细微理解,并突出了干预的潜在神经点.

关键词:

禁欲是一种禁欲.可卡因使用障碍是可卡因使用障碍.功能磁力共振成像 (fMRI) 是一种功能共振成像.反应抑制抑制的反应.停止信号任务的任务

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