相关实验视频

Updated: Jul 12, 2025

Identification of Circular RNAs using RNA Sequencing

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

循环RNA_0000285:一种新的双刃剑循环RNA在人类恶性瘤中

Mohsen Ahmadi¹, Firouzeh Morshedzadeh², Soudeh Ghafouri-Fard¹

¹Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pathology, research and practice

|October 23, 2023

概括

循环RNAs (circRNAs),像circ_0000285,通过与microRNAs (miRNAs) 相互作用,在癌症中发挥作用. 本综述总结了circ_0000285的致癌作用和各种癌症的潜在相互作用.

科学领域:

分子生物学分子生物学
遗传学是一个遗传学.
在瘤学瘤学.

背景情况:

循环RNAs (circRNAs) 是由背部拼接形成的共闭合的RNA分子.
失调的circRNAs,如circ_0000285,通过microRNA (miRNA) 相互作用影响基因转录.
circ_0000285,来自HIPK3基因,作为竞争的内源性RNA为多个miRNAs.

研究的目的:

审查circ_0000285在人类癌症中的致癌作用.
总结来自细胞系,动物模型和人体组织的实验证据.
为了确定潜在的miRNA和RNA结合蛋白相互作用与circ_0000285.5.

主要方法:

在癌症中研究circ_0000285的文献综述.
从体外,体内和人体研究中分析实验数据.
对miRNA和RNA结合蛋白的生物信息预测目标.

主要成果:

在各种癌症中,circ_0000285的调节经常失调.
circ_0000285与癌症患者的预后不佳和临床病理特征有关.
circ_0000285作为几个miRNA的竞争性内源RNA,影响癌症的进展.

结论:

circ_0000285在多种癌症类型中表现出显著的致癌作用.
了解circ_0000285相互作用可能为癌症提供新的治疗策略.
对circ_0000285目标的进一步研究可能会揭示癌症机制的新见解.

关键词:

生物信息学是一种生物信息学.生物标志物生物标志物癌症癌症癌症癌症圆周_0000285 在线观看这是循环RNARNA.诊断诊断诊断诊断诊断这就是米RNA.幸存的生存方式

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Use of Alu Element Containing Minigenes to Analyze Circular RNAs

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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

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