通过观察学习诱导的安慰剂低和Nocebo高可能很难在实验室环境中解开纠
Stefanie H Meeuwis1, Joanna Kłosowska1, Elżbieta A Bajcar1
1Pain Research Group, Institute of Psychology, Jagiellonian University, Kraków, Poland.
The journal of pain
|October 23, 2023
概括
通过观察学习 (OBL) 通过塑造期望来影响疼痛感知. 看到别人经历疼痛缓解或增加会影响自己的疼痛,期望在调节这些安慰剂和无效疗法效应方面发挥着关键作用.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 疼痛研究 疼痛研究
背景情况:
- 观察性学习 (OBL) 可以诱导安慰剂低痛解症和无助剂高痛解症.
- 只有有限的数据可以比较这些效应以及期望和同理心的作用.
研究的目的:
- 研究观察性学习 (OBL) 如何调节疼痛感知.
- 为了比较OBL诱导的安慰剂和无效疗法效应.
- 检查预期在OBL诱导的疼痛调节中的调解作用.
主要方法:
- 105名健康参与者被随机分配到安慰剂OBL,noceboOBL或对照组.
- 参与者观察到一个模拟在假药膏应用后缓解或增加疼痛的模型.
- 使用热刺激来评估疼痛,以及自我报告的期望和生理测量 (皮肤导电水平).
主要成果:
- 一个显著的三向相互作用证实了OBL调节疼痛 (F(2, 93) = 6.08,P = .003, ηp2 = .12).
- 诺塞博 (Nocebo) OBL组的疼痛显著增加,特别是在使用膏的手臂上 (P ≤ .007).
- 接受安慰剂的OBL组在对侧手臂和膏手臂 (P < .001) 中经历了较高的疼痛,这表明潜在的nocebo学习.
结论:
- 观察性学习显著调节疼痛感知,主要是通过期望.
- 在OBL范例中,区分安慰剂低痛解和nocebo高痛解可能是具有挑战性的.
- 这些发现对了解OBL,安慰剂效应及其临床应用有影响.
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