支持睡眠障碍与安慰剂效应损害之间的关系的临床表现
Yang Wang1, Jeril Varghese2, Salim Muhammed2
1Department of Pain and Translational Symptom Science, School of Nursing, University of Maryland, Baltimore; Placebo Beyond Opinions Center, University of Maryland School of Nursing, Baltimore.
The journal of pain
|October 23, 2023
概括
患有慢性疼痛和失眠或睡眠质量不佳的个人经历了减少的安慰剂效应. 这突显了睡眠障碍与慢性疼痛患者疼痛调节之间的关键联系.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 疼痛管理 疼痛管理
背景情况:
- 失眠和睡眠质量差与许多健康问题有关,包括慢性疼痛.
- 下降疼痛调节系统 (如安慰剂效应) 对慢性疼痛患者睡眠质量的影响尚不清楚.
研究的目的:
- 为了研究睡眠障碍 (失眠和睡眠质量差) 与慢性疼痛患者的安慰剂效应之间的关系.
- 在经历不同睡眠质量的慢性疼痛患者和无疼痛对照者中比较安慰剂效应.
主要方法:
- 一项涉及277名患有慢性疼痛的参与者和189名无疼痛对照者的横截面研究.
- 使用热热刺激诱导安慰剂效应,使用经典条件和口头建议.
- 评估了失眠严重程度 (失眠严重程度指数) 和睡眠质量 (匹兹堡睡眠质量指数).
主要成果:
- 患有慢性疼痛和失眠的参与者与患有慢性疼痛但没有失眠的参与者相比,表现出较小的安慰剂效应.
- 慢性疼痛患者的睡眠质量差与降低安慰剂效应有关.
- 临床焦虑部分介导了睡眠障碍和安慰剂效应之间的关系.
结论:
- 患有慢性疼痛,失眠和/或睡眠质量差的个体表现出明显减少的安慰剂效应.
- 实验前一晚的睡眠连续性没有影响安慰剂效应的大小.
- 研究结果表明,睡眠障碍可能会影响慢性疼痛患者的安慰剂止痛疗法的有效性.
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