超分辨率的QSM在很少或没有额外的成像时间 (NATIve) 使用2D EPI成像在3个直角平面
Beata Bachrata1, Steffen Bollmann2, Jin Jin3
1High Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Austria; Karl Landsteiner Institute for Clinical Molecular MR in Musculoskeletal Imaging, Vienna, Austria; Department of Medical Engineering, Carinthia University of Applied Sciences, Klagenfurt, Austria.
NeuroImage
|October 23, 2023
概括
我们开发了NATIve QSM,这是一种使用2D EPI扫描的超快速定量易感性测绘技术. 这种方法显著减少了扫描时间和运动器件,使神经疾病患者的QSM成为可能.
科学领域:
- 神经成像是一种神经成像.
- 医学物理 医学物理
- 放射学 放射学是一门学科.
背景情况:
- 定量敏感性映射 (QSM) 提供了对神经疾病的洞察力.
- 传统的QSM方法使用长,运动敏感的3D扫描 (5-10分钟).
研究的目的:
- 开发一种超快速和运动强大的QSM采集技术.
- 为了使患者在无法长时间保持静止状态时能够进行QSM.
主要方法:
- 使用了三个直角的2D同时多切片EPI扫描 (1毫米内平面分辨率).
- 用于共同注册和超分辨率重建的员工最小变形平均值.
- 实现了大约12秒的净获取时间 (NATIve QSM).
主要成果:
- 在健康受试者中,NATIve QSM与传统的3D GRE QSM显示出良好的一致性.
- 多发性硬化症患者的损伤可视化和易感度值与3D GRE QSM相似.
- NATIve QSM的速度是3D GRE的25-50倍,是3D EPI的3-5倍.
- 与3D方法相比,2D技术显示出更高的运动稳定性.
结论:
- NATIve QSM是一个可行的,超快的,运动强大的QSM替代品.
- 这种技术可以将QSM应用扩展到具有运动挑战的患者群体.
- 能够更有效地研究神经系统疾病中的铁积累和脱髓化.
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