怀孕期间母亲的维生素D摄入量和儿童健康结果
Erdenebileg Nasantogtokh1, Davaasambuu Ganmaa2, Shirchinjav Altantuya1
1National Center for Maternal and Child Health, Mongolia; Mongolian National University of Medical Sciences, Mongolia.
The Journal of steroid biochemistry and molecular biology
|October 23, 2023
概括
孕妇在怀孕期间服用维生素D补充剂,特别是每日600 IU以上的剂量,显著减少了在2岁以下的儿童中患风,呼吸系统疾病和腹疾病的情况. 母亲摄入较高的维生素D可以保护后代免受常见的童年疾病.
科学领域:
- 孕产妇和儿童的健康
- 营养流行病学 营养流行病学
- 公共卫生 公共卫生
背景情况:
- 怀孕期间母亲的维生素D状况对胎儿发育和婴儿健康至关重要.
- 低母体维生素D水平与不良的儿童健康结果有关,包括恶心病和呼吸道感染.
- 怀孕期间最佳的维生素D剂量需要进一步调查.
研究的目的:
- 评估不同产前维生素D补充剂剂对2岁以下儿童健康结果的长期影响.
- 为了确定母体维生素D摄入量与子孙中风,呼吸道疾病和胃肠道问题的发病率之间的剂量反应关系.
- 评估较高维生素D剂量对常见儿童疾病的保护作用.
主要方法:
- 一项随机,双盲,临床试验的后续研究,涉及蒙古的311名儿童.
- 孕妇从怀孕12-16周开始每天接受维生素D剂量 (600,2000或4000 IU).
- 通过问卷和体检,在3,6个月和24个月评估了儿童健康结果 (风,呼吸系统疾病,腹/吐).
主要成果:
- 与高剂量组相比,母亲每天服用600 IU维生素D的婴儿患病的发病率显著更高 (15.6%).
- 肺炎发病率在600 IU/day组 (35.0%) 与4000 IU/day组 (31.5%) 相比显著更高.
- 较高的母体维生素D摄入量 (每天2000-4000 IU) 与2岁儿童患呼吸系统疾病,恶心病和腹疾病的风险降低有关.
结论:
- 产前维生素D补充剂的剂量超过600 IU/天,可显著保护儿童早期免受恶心病,呼吸道感染和腹疾病的侵害.
- 在怀孕期间,适当的母体维生素D水平对于预防常见的儿童疾病至关重要.
- 在怀孕期间服用更高剂量的维生素D补充剂对儿童健康结果有明显的益处.
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