与代谢功能障碍相关的稳态性肝病促进乙型肝炎表面抗原血清清除和血清转化
Shang-Chin Huang1, Tung-Hung Su2, Tai-Chung Tseng3
1Department of Internal Medicine, National Taiwan University Hospital Bei-Hu Branch, Taipei, Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
与代谢功能障碍相关的脂肪性肝病 (MASLD) 与慢性乙型肝炎 (CHB) 患者的乙型肝炎表面抗原 (HBsAg) 血清和血清转化率较高有关. 这些代谢问题有助于实现CHB的功能治疗.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 代谢疾病 代谢疾病
背景情况:
- 乙型肝炎病毒 (HBV) 感染的功能治愈是由乙型肝炎表面抗原 (HBsAg) 血清清除所定义的.
- 代谢功能障碍相关的脂肪性肝病 (MASLD) 对慢性乙型肝炎 (CHB) 患者的HBsAg血清清除的影响尚不清楚.
研究的目的:
- 调查MASLD与HBsAg血清清除和血清转化率在未接受治疗的,B型肝炎e抗原 (HBeAg) 阴性CHB患者中的关联.
- 确定代谢功能障碍是否对CHB的功能治愈具有添加效应.
主要方法:
- 分析了4084名未经治疗的HBeAg阴性CHB患者的队列.
- 根据新提出的标准诊断出MASLD.
- 在患有MASLD和没有MASLD的患者之间,对HBsAg血清清除/血清转换的累积发病率进行了比较,并对混因素进行了调整.
主要成果:
- 患有MASLD的CHB患者与没有MASLD的患者相比,具有较低的基线HBsAg和HBVDNA水平.
- MASLD与HBsAg血清清除 (aHR, 1.43) 和血清转化 (aHR, 1.37) 的更高可能性显著相关.
- 观察到个体代谢功能障碍的附加效应,促进HBsAg血清清除.
结论:
- 同时的MASLD与未经治疗的HBeAg阴性CHB患者的HBsAg血清和血清转化率的改善有关.
- 代谢功能障碍在增强CHB的功能治愈方面发挥着累积作用.
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