在患有类风湿性关节炎的患者中对脑血管疾病进行神经病理学评估
Rachel A Larsen1, Eleni Constantopoulos1, Chanakya Kodishala2
1Department of Laboratory Medicine and Pathology, Neuropathology Mayo Clinic, Rochester, MN, USA.
Rheumatology (Oxford, England)
|October 23, 2023
概括
类风湿性关节炎 (RA) 患者表现出与对照人群相似的脑血管疾病,除了基底质中更严重的血管变化. 这表明RA可能会影响特定的大脑区域,即使没有痴呆症.
科学领域:
- 神经学 神经学
- 类风湿病学 类风湿病学
- 病理学 病理学 病理学
背景情况:
- 活性类风湿性关节炎 (RA) 与心血管和周围血管疾病风险的增加有关.
- 了解RA中的脑血管变化对于全面的患者护理至关重要.
研究的目的:
- 为了比较RA和无RA患者的脑血管病理.
- 为了调查神经退行性疾病存在或不存在的这些变化.
主要方法:
- 匹配的尸检队列研究 (32名RA患者,32名对照).
- 神经病理学检查和脑血管疾病评估,使用卡拉里亚和斯特罗齐克尺度.
- 从医疗记录中收集的临床痴呆症诊断.
主要成果:
- 在RA和对照组之间,痴呆症和阿尔茨海默病的患病率相似.
- 在脑粉样血管病变,微心脏病发作或心脏病发作中没有显著差异.
- 关节炎患者在基底质中表现出更严重的血管变化 (p=0.04).
结论:
- 在控制神经退行性疾病时,RA和非RA患者的脑血管病理在很大程度上是相似的.
- 关节炎患者可能会出现更明显的脑血管疾病,特别是在基底腺体内.
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