分离前额眼球运动对空间工作记忆和运动准备的贡献
Donatas Jonikaitis1, Behrad Noudoost2, Tirin Moore3
1Department of Neurobiology and Howard Hughes Medical Institute, Stanford University, Stanford, California 94350.
概括
前视野 (FEF) 中的神经元主要支持眼动准备,而不是空间工作记忆. 无效化FEF损害了眼睛的运动,但没有记忆力,当与运动规划分离.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 灵长类动物研究研究
背景情况:
- 脊侧前额叶皮质 (PFC) 中的神经元,包括前额眼球 (FEF) 中的神经元,在工作记忆任务中表现出持续的活动.
- 众所周知,FEF有助于眼运动和视觉空间注意力.
- 在同时支持运动规划和视觉空间工作记忆方面,FEF持续活动的确切作用仍然不清楚.
研究的目的:
- 调查FEF持续延迟活动是否有助于运动规划,视觉空间工作记忆或两者兼而有之.
- 为了分离FEF活动在记忆指导的萨卡德与空间记忆表示中的作用.
主要方法:
- 男性子接受了空间工作记忆任务的训练,旨在将记住的位置与计划的眼动分开.
- 为了评估行为表现,进行了特定FEF站点的非激活.
- 在不同的任务条件下,分析了在眼动执行和记忆回忆方面的缺陷.
主要成果:
- FEF 失活会损害记忆引导式动 (MGS) 和当记忆目标与计划动作相匹配时的性能.
- 当记住的位置与所需的眼动反应分离时,记忆性能不受影响.
- 不活化始终导致眼睛运动缺陷,但在与运动输出分离时,对空间工作记忆的影响最小.
结论:
- 在FEF中持续延迟活动主要涉及眼动的准备和执行.
- 在空间工作记忆中FEF的作用可能是其在运动规划中的作用的次要作用.
- 这些发现澄清了FEF神经活动对认知运动功能的具体贡献.
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