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Updated: Jul 12, 2025

Advanced Confocal Microscopy Techniques to Study Protein-protein Interactions and Kinetics at DNA Lesions
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Published on: November 12, 2017

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紫外线诱导的G4DNA结构招募ZRF1,防止紫外线诱导的衰老

Alessio De Magis1,2, Michaela Limmer1,2, Venkat Mudiyam1

  • 1Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.

Nature communications
|October 23, 2023
PubMed
概括

紫外线照射导致G-四重复 (G4) DNA结构积累,导致ZRF1蛋白缺失时衰老. 这种缺失会损害DNA修复,并提高DDB2的调节,导致细胞衰老.

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