来自肠道微生物组的氨调节了宿主体的压力脆弱性
Pei Wang1, Peng-Fei Wu1,2,3,4, Hua-Jie Wang1
1State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Nature metabolism
|October 23, 2023
概括
肠道微生物产生氨,这是一种有益的化合物,有助于维持大脑的谷氨胺水平. 这个过程支持压力弹性,可以针对抑郁症进行治疗.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 代谢科学 代谢科学
背景情况:
- 氨被认为是一种神经毒性废物.
- 内生氨的有益作用,特别是来自肠道微生物群的有益作用,在很大程度上尚未被探索.
- 应激反应中的肠-大脑轴通信需要进一步阐明.
研究的目的:
- 调查内源性氨在宿主压力脆弱性中的有益功能.
- 探索肠道微生物代谢和大脑谷氨酸可用性之间的联系.
- 确定与压力有关的疾病的潜在治疗点.
主要方法:
- 利用雄性小鼠模型研究慢性压力及其对血液氨水平的影响.
- 研究了尿酶阳性肠道微生物群的作用,包括Streptococcus thermophilus.
- 评估行为变化,大脑中的谷氨胺水平和GABAergic功能,以应对氨调节.
- 研究了化 (NH4Cl) 的治疗潜力.
主要成果:
- 慢性压力通过改变肠道尿素酶阳性微生物群来降低血氨.
- 热杆菌 (Streptococcus thermophilus) 逆转了压力引起的类似抑郁症的行为.
- 药物抑制肠道氨的产生增加了压力脆弱性.
- 低血氨水平与减少大脑谷氨胺和皮质GABAergic功能障碍有关,增加了压力脆弱性.
- 化治疗在抑郁症模型中挽救了行为和GABAergic缺陷.
结论:
- 来自肠道的氨在宿主压力缓冲中发挥着有益作用,通过维持大脑的谷氨胺可用性来维持宿主压力缓冲.
- 来自肠道微生物群的氨会通过肠-大脑信号通路影响宿主的情绪行为.
- 调节肠道氨产量为与压力相关的疾病和抑郁症提供了潜在的治疗策略.
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