装有外体的可降解聚合物微囊,用于治疗玻璃关节疾病
Han Bao1,2, Ying Tian1,2, Haixin Wang1
1State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, P. R. China.
Nature biomedical engineering
|October 23, 2023
概括
装有外体的可降解微囊显示出对玻璃关节疾病的治疗潜力. 这些外体封装微囊恢复视网膜厚度,减少炎症,提供新的治疗选择.
科学领域:
- 生物医学工程 生物医学工程
- 眼科医生 眼科 眼科
- 再生医学是一种再生医学.
背景情况:
- 基于细胞的治疗玻璃关节疾病往往依赖于膜机制.
- 外体介导着对体信号传递,而微囊则提供持续释放和降解.
- 开发先进的药物输送系统对于治疗复杂的眼睛疾病至关重要.
研究的目的:
- 为了研究外体载的可降解的多酸 (乳酸-co-糖酸) 微囊对玻璃关节疾病的治疗疗效.
- 评估外体的持续释放和微囊的降解概况.
- 评估这种新型治疗方法在临床前模型中的潜力.
主要方法:
- 制造微米孔聚 (乳酸-co-糖酸) 微囊,封装由间酶体干细胞或调节性T细胞衍生的外体.
- 在视网膜缺血-再输损伤和真菌细菌性脑膜炎的小鼠模型中静脉内注射微囊.
- 在接受治疗的人群中评估视网膜厚度的恢复和炎症细胞的减少.
- 评估外体细胞释放动力学和微囊随时间的降解.
主要成果:
- 在对视网膜缺血-再输液损伤的小鼠模型中,对外体载入微囊的静脉内注射导致了持续的外体释放和恢复视网膜厚度.
- 在小鼠和非人类灵长类动物模型中,微囊显著降低了炎症细胞水平.
- 微囊在一个多月的时间里显示出受控的降解和外体细胞释放.
- 成功制备了冷化外体细胞封装微囊,表明储存和运输的潜力.
结论:
- 装有外体的可降解微囊代表了对玻璃甲状腺疾病的有前途的治疗策略.
- 这种输送系统有效地恢复视网膜结构,并在临床前模型中调节炎症.
- 溶解解的能力表明,在眼科中临床应用具有实际优势.
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