估计的膜过率与认知障碍之间的关联:苏伊塔研究
Ahmed Arafa1,2, Haruna Kawachi3,4, Chisa Matsumoto3,5
1Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan. ahmed011172@med.bsu.edu.eg.
概括
通过估计的膜过率 (eGFR) 测量功能下降,与日本成年人的认知障碍有关. 治疗慢性病 (CKD) 可能有助于预防认知能力下降.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 慢性病 (CKD) 影响功能,估计膜过率 (eGFR) 作为关键指标.
- 认知障碍是一个日益严重的公共卫生问题,其与CKD的关联需要进一步调查.
研究的目的:
- 在一个大型的日本队列中调查降低eGFR和认知障碍之间的关联.
- 为了确定与不同阶段的EGFR降低相关的认知障碍的风险.
主要方法:
- 采用来自苏伊塔研究的6215名参与者的数据进行的横截面研究.
- 认知障碍被定义为迷你精神状态检查 (MMSE) 得分 ≤ 26.
- 逻辑回归分析以计算基于eGFR水平 (≥60,45-59.9和<45毫升/分钟/1.73米2) 的认知障碍的几率比率 (OR).
主要成果:
- 轻度 (eGFR 45-59.9) 和中度至重度 (eGFR <45) 的EGFR降低都与认知障碍有显著的关联.
- 认知障碍的OR为1.49 (95% CI: 1.22-1.83) 对于轻度减少和2.35 (95% CI: 1.69-3.26) 对于中度至重度减少.
- EGFR增加10毫升/分钟/1.73米2与认知障碍的几率下降4.8%有关 (p趋势<0.001).
结论:
- 降低EGFR显著与认知障碍风险增加有关.
- 这些发现凸显了治疗CKD对于预防认知能力下降的重要性.
- 早期发现和治疗功能障碍可能在维持认知健康方面发挥关键作用.
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