复发性粘性尾腺癌的重复细胞还原和高温腹腔内化学疗法:一种可行的治疗策略,具有可证明的益处
Neal Bhutiani1, Travis E Grotz2, Seth J Concors1
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Annals of surgical oncology
|October 23, 2023
概括
重复细胞还原性手术 (CRS) 和高热性腹腔内化学疗法 (HIPEC) 为一些尾粘膜腺癌复发的患者提供了生存益处,与初始治疗相比.
科学领域:
- 手术瘤学手术瘤学
- 胃肠道瘤学 胃肠道瘤学
- 腹腔周围的恶性瘤
背景情况:
- 粘性尾腺癌经常在外科手术后在腹腔内复发.
- 之前的研究表明,重复细胞还原性手术 (CRS) 和高热性腹腔内化疗 (HIPEC) 可以改善特定病例的生存率.
- 这项研究证实了这些发现在一个大规模的癌症中心.
研究的目的:
- 为了评估重复CRS/HIPEC对复发的尾粘膜腺癌的疗效.
- 为了比较重复CRS/HIPEC与初始CRS/HIPEC的结果.
- 评估复发性疾病的生存益处与单独的全身化疗相比.
主要方法:
- 用CRS/HIPEC (2004-2021) 治疗的粘膜尾腺癌患者的回顾性分析.
- 分为初始治疗和复发性疾病组的分层.
- 纳入标准: 完整的CRS/HIPEC.
主要成果:
- 在437名患者中,有50名患者 (11.4%) 接受了重复的CRS/HIPEC治疗.
- 复发组接受了更多的氧沙/思沙输液 (35%/44% vs 4%/1%) 和住院时间更短 (10 vs 13 天).
- 在30天并发症或90天死亡率上没有显著差异;可比的无复发存活率;在复发性疾病中,总体存活率优于单独的全身化疗.
结论:
- 重复CRS/HIPEC可为复发性尾粘膜腺癌的选定患者提供生存益处.
- 结果与初级CRS/HIPEC可比,可能优于单独的全身疗法.
- 护理应由多学科的团队在高人数的中心管理.
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